To cure the illness in the brain glioblastoma, the Gliadel wafer, as the first FDA-approved chemotherapy, was available on the market since 1997. Due to the complex studies in vivo, the numerical methods (Finite Element Method)  and tools (AFEPack) may be the effective way to simulate the dynamic process in the brain,  such as the pressure in the normal brain tissue and the change of concentration of the drug release in brain tumor.